From material mechanisms to clinical needs

This direction aims to use self-assembled monolayers (SAMSAMs) and nanofiber scaffolds as model surfaces and scaffolds to systematically study how surface chemistry, scaffold spatial structure and stiffness, and external loads (fluid shear stress, mechanical tensile stress) regulate: protein adsorption (focusing on conformational changes, adsorption strength, and protein-layer surface energy), thereby understanding the mechanisms by which cell shape (osteoblasts, mesenchymal stem cells, etc.) is influenced, and dissecting the materials- and mechanics-based mechanisms by which cell shape controls cell fate, ultimately guiding the design and manufacture of biomaterials, scaffolds, or bioreactors to form functional tissues.

         This direction aims to address the problems of bone nonunion and slow bone repair and regeneration by integrating knowledge from biomaterials, biomechanics, cell biology, and medicine to conduct basic and applied research on bioinspired /smart artificial bone, so as to gain a deeper understanding of the causes of related diseases and develop novel bone repair technologies.

This direction aims to use the main structural protein of tendon tissue (I-type collagen fibers) to construct oriented2D and 3D biomimetic tendon tissues, to explore their regulatory mechanisms on stem cell fate and their in vivo repair effects, and to provide a possibility for effectively repairing defective tissues with tissue-engineered tendons composed of the three elements of scaffold materials, stem cells, and growth factors.

This direction aims to construct mechanical instability models to explore the effects and mechanisms of mechanical instability on soft tissue inflammation and angiogenesis in the osteoarticular system, and further elucidate its role in soft tissue degeneration in the osteoarticular system and the underlying mechanobiological mechanisms; on this basis, optimize the design of biomimetic scaffolds, and explore the effects and mechanisms of scaffold implantation and mechanical intervention on the repair of mechanically unstable degenerated tissues.